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Mechanisms include: Restoration of endothelial nitric oxide synthase (eNOS) Upregulation of VEGF and FGF-2 (fibroblast growth factor 2) Reduction of oxidative stress and cytokine-induced apoptosis BPC-157 preserved endothelium-dependent vasodilation via upregulation of eNOS and suppression of vascular inflammation. Gwyer Findlay et al., Peptides 4

3-D cell discs were formed by culturing vascular smooth muscle cells in collagen first and then 3-D discs with similar size were incubated in different media for 24 h

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The genetic instability ulteriorly leads to genetic alterations in cells, such as somatic mutations of PIK3CA and TP53 , which are non-inherited