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Is Ozempic (semaglutide) safe to use in a patient with end-stage renal disease (ESRD) and impaired renal function, with a most recent glomerular filtration rate (GFR) of severe impairment?

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[0005] In view of the disadvantages for marketed semaglutide products, a drug delivery system for nasal mucosa is an alternative and promising choice since the drug can directly enter into blood circulation from absorption sites, thus high GI degradation and liver metabolism can be completely bypassed, as well as convenience and acceptance to the general public

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