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Table 2 shows NF-B also regulates cytokines and growth factors that remodel the tumor microenvironment to favor metastasis and immune evasion [48]

This adaptation is a normal biological response, not a sign of treatment failure

Notably, the serotonergic, dopaminergic and glutamatergic neurotransmitter systems that are directly involved in many psychological disorders are closely coupled to mitochondrial metabolism, modulated by the HPA axis and represent independent mechanisms that contribute to gliosis and excitotoxicity

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