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Secondary outcomes encompass MACEs, including stroke (either ischemic or hemorrhagic), acute myocardial infarction (AMI), cardiac arrest, cardiogenic shock or death, as well as major adverse kidney events (MAKEs), which is defined as a composite of dialysis dependence, an eGFR less than 15 mL/min/1.73 m, or death

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Inhibiting this enzyme is examined in the literature for its effect on intracellular NAD availability , which is why 5-Amino-1MQ is frequently used as a research tool in NAD pathway and cellular energy-metabolism studies rather than as a substitute for NAD itself

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