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demonstrated that brain-specific BDNF conditional knockout mice present worse cardiac remodeling and function after MI compared with control mice suggesting a cardioprotective role of neuronal BDNF production after MI [55]
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The clear influence of therapeutic GLP-1 analogs on the physiology of the digestive system as well as the stability and diversity of the gut microbiota deserves special attention because disorders of the gut-brain axis homeostasis also appear to be an important, although so far somewhat understudied factor, which may lead to the development of depression
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