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Thus, we have shown an age-related decrease of GSH levels in leukocytes from mice, which is more striking in those from PAM(35,58), and that the administration of GSH precursors, such as tioproline and N-acetylcysteine in both mice and humans, increases those levels as well as improves the immune cell functions and its redox state(35,58,88), being able to increase life expectancy in normal laboratory animals(97) and in PAM(35,58)

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