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The 6.6 percentage-point gain from adding cagrilintide to semaglutide is the cleanest existing read on what amylin layering buys you on top of an incretin agonist
This is because both compounds affect gastrointestinal motility and appetite through their respective mechanisms, and layering them too aggressively creates compounding GI effects that can derail compliance
The cagrilintide dosage with retatrutide would theoretically combine amylin pathway activation with this triple-agonist approach
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