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The high GH levels, together with the often severe IGF-1 deficiency, will lead to a severe catabolic state, including significant lipolysis and proteolysis, comparable to extended fasting during a hunger strike, for instance [26]
This class of drugs has been used for almost two decades to treat diabetes, although it is possible new side effects will become evident with more users and newer drugs
Evidence-based strategies include dietary reassessment with a registered dietitian, increasing physical activity to 150 minutes weekly, optimising protein intake, and considering dose adjustment under medical supervision
Community reconstitution protocols describe adding 2 mL of bacteriostatic water to the vial, directing the stream toward the glass wall rather than the lyophilized powder, and swirling gently shaking is avoided
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