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Villarroya, F., Peyrou, M
FOXO4-DRI theoretically has higher selectivity by targeting the FOXO4-p53 interaction that is specifically elevated in senescent cells
While the majority of published data originates from the Sikiric laboratory in Zagreb, independent groups have increasingly contributed to the literature, and the peptide remains a subject of active investigation across multiple areas of preclinical science.
The metabolism and clearance of both components may be affected by significant liver disease, and patients with severe hepatic impairment should be monitored closely if treatment is deemed necessary
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