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For patients weighing 150 kg (330 pounds) or more, healthcare providers increase the dose to 1 gram to ensure adequate blood concentrations above the bacterial minimum inhibitory concentration for approximately 50 hours. This ceftriaxone monotherapy approach emerged after mounting azithromycin resistance prompted CDC to abandon dual-drug therapy in 2020, leaving gonorrhea treatment dependent on essentially one antibiotic classa precarious situation as resistance continues evolving globally

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Wang et al., 2019), improving ovarian function

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