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When a GLP-1 medication reduces appetite, it does so partly by modulating dopamine signaling in the brains reward system
Other differences include half-life (tirzepatide ~5 days, semaglutide ~7 days), dosing ranges, and available formulations
Semaglutide is new to the neighborhood as a weight loss drug, receiving its FDA approval in 2021
Basic Profile of Exenatide
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