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All participants in the oral semaglutide treatment arms started the study at a dose of oral semaglutide 3 mg once-daily and then increased the dose in a step-wise approach at four-week intervals until reaching their final randomized maintenance dose of 7 mg (via a step at 3 mg) or 14 mg (via steps at 3 mg and 7 mg)

Common initial side effects include mild nausea, reduced appetite, and occasional constipationmost of which improve within 24 weeks as your body adapts

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