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Insurance coverage and guidance from a healthcare professional are also important for safe, optimal results
Given that large, long-duration studies may be needed to demonstrate that a disease-modifying therapy is engaging the intended target and modifying disease progression, biomarkers can play an important role in phase 2 clinical trials to demonstrate proof of concept prior to initiating trials intended to demonstrate clinical benefit (Cummings, 2019
Three systems adjusting simultaneously requires more adaptation time
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