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Several clinical circumstances involve the oxidation of tetrahydrobiopterin (BH4) and mitochondrial electron transport, as well as the inactivation of nicotinamide-adenine dinucleotide phosphate (NADPH) oxidase, xanthine oxidase (XO), cyclooxygenase, and uncoupled endothelial nitric oxide synthase (eNOS) (73)

Furthermore, other post-translation modifications of keap-1 (glycosylation, phosphorylation, glutathionylation and SUMOylation) is also reported indicating that the type of modifier is critical to determine how Keap-1 is chemically modified and Nrf2 is released (Song et al., 2023)

General medicine, family medicine, or internal medicine covers symptoms like fever, cough, flu, infections, or a routine check-up to keep a long-term condition in check