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Several factors can cause glutathione deficiency, such as poor nutrition, exposure to environmental toxins, chronic stress, and the natural aging process
Alteration in the gut microbiota composition is determined by increase in the permeability of the gut barrier and immune cell activation, leading to impairment in the BBB function that promotes neuroinflammation, neuronal loss, neural injury, and eventually AD (Megur et al
The ultimate aim of any experimental system should be replication of human pathophysiology which is central to translate findings to the clinic
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