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K.MeinekeI.Godtel-ArmbrustU.BrockmollerJ.WojnowskiL.2006Dominant contribution of P450 3A4 to the hepatic carcinogenic activation of aflatoxin B1.19577586 46
Lipohypertrophy develops at the overused site, drug absorption becomes unpredictable, and your carefully optimized timing becomes meaningless because the pharmacokinetics are no longer reliable
Even higher thresholds apply in the Highly Specialized Technologies (HST) program, intended for ultra-orphan diseases: here allowances can reach on the order of 100k300k per QALY ( [5] ), recognizing the exceptional rarity and need for innovation
A study in female patients with obesity who were prescribed a 925 kcal diet for 16 weeks followed by a 12001500 kcal diet for 32 weeks showed 11% weight loss in the first 2 months with reductions in triglycerides and total cholesterol by 22.7% and 15.7% respectively [29]
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