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Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers
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Mesoporous silica nanoparticles have been utilized for selective internalization in tumor cells with endosomal escape, where the particles were decorated by self-immolative GSH-cleavable linkers as smart gatekeepers to prevent premature release 81
Once activated, ERK1/2 is transferred to the nucleus, where it phosphorylates transcription factors such as c-Myc and c-Fos, leading to the expression of genes responsible for cellular regulations such as cell proliferation, differentiation, and migration
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