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Rigorous, long-term prospective trials in asymptomatic, high-risk populations such as individuals with type 2 diabetes, obesity, or APOE4 carrier status are required to definitively validate or refute this hypothesis
Gonzlez JA, Reimann F, Burdakov D
The STEP trials found that people who stayed on semaglutide for two years maintained their weight loss and continued to show improvements in HbA1c, fasting glucose, triglycerides, and inflammatory markers
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