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Furthermore, treatment with Fer-1 relieved the inhibition of PDO growth that had been induced by ACTL6A KD, and enabled organoids regained a cystic structure (Fig

Serine metabolism: some tumors take the road less traveled

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Or, the glutamate can be further converted to GABA using the GAD1 enzyme, which requires the active form of vitamin B6 (P5P) as a cofactor.[ref] Genetic variants that reduce the conversion of B6 to its active form, P5P, could therefore impact GABA synthesis and GABAergic neurons