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However, significant weight loss itself affects thyroid hormone requirementspatients often need lower levothyroxine doses as they lose weight, creating a therapeutic adjustment period that demands regular lab monitoring

Tirzepatide is administered as a once-weekly subcutaneous injection, with dosing typically initiated at 2.5 mg (primarily for tolerability) and gradually titrated upward every 4 weeks based on glycemic response and tolerability

Study amount groups What the published trial records listed

However, staying hydrated on the day of your injection is highly recommended to support kidney function and general well-being