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Because it avoids hepatic first-pass metabolism, circulating citrulline is primarily cleared by the proximal renal tubule, where it is enzymatically converted to arginine
Patients typically experience minimal discomfort during the insertion of the IV line
The bigger lesson is simple: obesity treatment is chronic care
Participants who had lost an average of 10.6% of their body weight over 20 weeks on semaglutide were then split into two groups: continue the medication, or switch to placebo
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