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In the CNS, laminin deficiency leads to BBB breakdown, characterized by reduced pericyte coverage, leukocyte extravasation, and altered expressions of VE-cadherin, claudin-5, and occludin, underscoring laminin's role in maintaining BBB integrity [51, 66,67,68]
The effects of delta-sleep-inducing peptide (DSIP) on wakefulness and sleep patterns in the cat
Tirzepatide has extensive Phase 3 and post-marketing safety data through Mounjaro and Zepbound
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