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Oral semaglutide is co-formulated with the absorption enhancer sodium N -(8-[2-hydroxybenzoyl]amino) caprylate, which facilitates the transcellular absorption of semaglutide across the gastric mucosa [2]
Recruitment strategy We will identify patients diagnosed with PCOS referred to the first endocrine check-up
check the NIHR 'Be Part of Research' portal or ClinicalTrials.gov for current recruiting studies
Common gastrointestinal effects reported with GLP-1 therapy include: Nausea (commonly reported, especially during dose escalation) Constipation or diarrhoea Abdominal discomfort or bloating Reduced appetite and early satiety Regarding bowel movement colour specifically, changes in stool colour are not listed as adverse effects in UK SmPCs for GLP-1 receptor agonists
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