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Vilsbll called attention to puzzling and/or unresolved aspects of the clinical activity and deliverability of non-peptide GLP-1 RAs: The lack of food/water restrictions with these oral therapies
Rothwell et al, 2012)
Compared to habitual fruit and vegetable intakes of 2 portions/day, the consumption of five portions per day for 16 weeks increased the alkalinity of the diet but failed to reduce markers of bone turnover (46)
This mechanism is why many patients feel full longer and eat less naturally
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