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An apparent paradox is that whereas GLP-1 increases glucose-stimulated insulin secretion in the isolated pancreas fulfilling the definition of an incretin but it lowers insulin secretion in physiologically relevant conditions [6, 10, 18]
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Symptoms such as brain fog and hot flashes reflect underlying changes in energy regulation, inflammation, and brain signaling
Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1alpha
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