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A large outcomes trial showed better weight loss and risk factor improvement compared with semaglutide, summarized in an American College of Cardiology trial review
No joint-specific human clinical trials exist
That discovery has led to the development of some of the most widely prescribed drugs in use today, treating obesity, type 2 diabetes, cardiovascular complications, and certain forms of severe liver disease
The time of day is less critical for weekly injections than the day itself, since the medication works over a full seven-day window
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