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These investigations are conducted exclusively in laboratory research settings
PhoQ detects acidic pH, low Mg, and cationic antimicrobial peptides (CAMPs), initiating autophosphorylation and subsequent phosphate transfer to PhoP
Earlier secretagogues such as GHRP-6 and GHRP-2 do trigger GH release, but they also switch on other pathways: they can raise cortisol (a stress hormone), raise prolactin, and drive a strong hunger response
One case in the broader dataset ran a continuous protocol for nine months
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