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To explore the potential underlying mechanism for overcoming drug resistance of the TYR-catalyzed prodrug approach, we evaluated the intracellular drug concentration in Cd and Pd1 + Pd2 + SA treatment groups
Investigations showed a normal chest radiograph/chest X ray (CXR), and spirometry showed moderate obstruction with FEV1 reversibility of 21% (but not back to normal) and even some air-trapping with FVC that improved by 19% with bronchodilator
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