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Glutathione is generally well tolerated by most adults, although some studies have linked long-term consumption with lower zinc levels
Furthermore, evidence indicates that NRF2 can transcriptionally upregulate CHAC1, as observed in ferroptosis-resistant melanoma cells where CHAC1 induction occurs independently of ER stress (Gagliardi et al., 2019) and modestly at the promoter level ( de novo GSH synthesis (Kre et al., 2023)
Clin Microbiol Rev (2020) 33(4):119
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