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The eight factors that will determine the impact of GLP-1s Influencing factor #1: The efficacy of GLP-1s Why it matters : This is the obvious one, but efficacy (for example, measured by lower blood sugar levels or magnitude of weight loss) will ultimately influence patient demand for GLP-1s (both in terms of initial demand as well as continued adherence), as well as physician willingness to prescribe these drugs
Second, the cycling recommendation, 8-12 weeks on followed by a 4-week off period, is based on the general principle applied to peptide therapies to prevent receptor desensitization and to allow assessment of lasting effects, rather than on direct MOTS-c cycling data
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