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And they were talking about the potential long-term consequences of that, both good and bad

This conversation should cover: The medical necessity of both treatments The expected duration of prednisolone therapy (short-term versus long-term) Individual risk factors, particularly regarding diabetes or prediabetes Realistic expectations about weight loss outcomes whilst on corticosteroids Monitoring requirements for blood glucose and other metabolic parameters The decision to use both medications should be individualised , weighing the clinical benefits of each treatment against potential complications

Collectively, these clinical observations highlight that isoform-specific targeting is essential not only for efficacy but also for minimizing off-target side effects, emphasizing the need for early-stage ADME/PK and selectivity profiling in the development of novel dual PDE1B/PDE10A inhibitors

and Yamanishi, T