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Animal Model:Neonatal Sprague-Dawley rats (male, 18-22g, postnatal day 7), hypoxic-ischemic brain damage (HIBD) model [2] Dosage:100 mg/kg Administration:Intraperitoneal injection, once daily, for 14 consecutive days starting 24 hours after HIBD induction Result:Brain injury: Reduced infarct volume by 40% compared to the HIBD control group as measured by triphenyltetrazolium chloride (TTC) staining
Mecanismos Moleculares Subyacentes: Aunque existen hiptesis fundamentadas sobre los mecanismos sinrgicos, se necesitan investigaciones ms profundas a nivel molecular para esclarecer con precisin cmo interactan los distintos pptidos y cules son las vas de sealizacin crticas que median estos efectos
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Disulfiram facilitates intracellular Cu uptake and induces apoptosis in human melanoma cells
