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While clinical trials conducted in Croatia in the early 2000s determined BPC 157 to be safe and effective in humans for the treatment of inflammatory bowel disease, there appears to be a lack of trials conducted in the U.S

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The mechanism centers on several overlapping actions: Angiogenesis activation: BPC-157 upregulates VEGF (vascular endothelial growth factor), promoting the formation of new blood vessels that supply oxygen and nutrients to damaged tissue