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Diarrhea and constipation may alternate, a confusing pattern that reflects the complex receptor interactions

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How Retatrutide Works Retatrutide at a glance Investigational drug Being studied for obesity treatment Part of the new weight loss medications category Targets GIP, GLP-1, and glucagon receptors Not FDA approved as of March 25, 2026 This three-pathway design is why retatrutide stands out

the more recently derived semaglutide is the key component in Ozempic and Wegovy, to which Novo holds the patent in the U.S