For people without deficiency, self-care should begin with basics that have stronger evidence: balanced meals, adequate protein, regular physical activity, hydration, sleep, and treatment of medical conditions that affect energy levels
Astrocytes supply GSH precursors to neurons, enabling detoxification of ROS generated during high metabolic activity (44, 47)
Patients typically ask about this combination because they are looking for a comprehensive wellness program rather than relying on a single peptide
Interestingly, while the role of GSTs has classically been associated to the modification of small molecules and the role of glutaredoxins to the deglutathionylation of proteins, it has recently been shown that human GSTO1-1 can deglutathionylate -actin, which should prompt us to consider proteins as GST substrates (Menon and Board, 2013)