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CP with a high proline content have been shown in vitro to inhibit DPP-IV activity (Reference Wang, Yu and Yokoyama72) , and in animal models, shown to stimulate GLP-1 secretion (Reference Iba, Yokoi and Eitoku73)
The bone also sends pain signals, as pores open in the bones and the nerves from the bone grow into the base of the cartilage
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