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Retatrutide and tirzepatide both work by copying natural hormones produced by your body, sending signals to your brain and digestive system
The overarching limitation is that most studies are preclinical and mechanistic and the extent to which they translate to human populations and behaviours is uncertain
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But it's a fairly simple on/off nucleus and if you alter its modulation it's not sophisticated enough that you can say, I want this behavior to go away, but I want that one to be preserved. The person has to make more of a choice-driven, I'm going to do this because it's good for me and I'd like to continue this. Not that it may feel as good as it used to
