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Additionally, the shift toward glycolysis can suppress antioxidant defenses, leaving cells more exposed to oxidative stress

Whereas the GLP-1 drug Ozempic is injected once weekly at 2 mg, Rybelsus is taken daily and requires a minimum dose of 14 mg to achieve comparable glycemic effects

(PMID 7658432) Dr

Patients on this protocol who also use metabolic support agents like Metformin should note that both agents activate AMPK, and physician oversight is warranted to avoid compounding effects on blood glucose that could theoretically cause hypoglycemia in susceptible individuals, though this has not been reported clinically with MOTS-c at standard doses