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BPC-157 works through four distinct pathways: it activates VEGF to create new blood vessels that deliver healing nutrients directly to damaged tissue, modulates inflammation while preserving beneficial immune responses, accelerates collagen synthesis for stronger cartilage and ligaments, and stabilizes cellular membranes to protect against further joint deterioration

In a study involving rats with hind limb ischemia, BPC-157 treatment was found to increase the expression of VEGFR2, subsequently activating the VEGFR2-Akt-eNOS pathway

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