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These are agonists, meaning that they act on the receptors, but they are not the exact molecule, which have been utilized now for many years for weight loss and diabetes control

A 2023 immunology review noted that sustained TNF-alpha inhibition (as seen with biologic drugs like adalimumab) increases opportunistic infection risk by 2030% over multi-year use

These studies will help determine optimal dosing, identify which patient populations benefit most, and establish the long-term safety profile for this dual-purpose application

Tirzepatide alone achieves 20.9% weight loss in SURMOUNT-1, which approaches or matches what phentermine-plus-semaglutide combinations achieve in observational data