(PubMed) Millard HR, Musani SK, Dibaba DT, et al
249 The key molecular event of KD treatment in promoting immunotherapy is the activation of AMPK, which phosphorylates PD-L1, resulting in its disrupted interaction with CMTM4 and subsequent PD-L1 degradation, which phosphorylates EZH2, resulting in improper PRC2 function and subsequently enhanced expression of IFN and antigen-presentation gene
Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme
But often these things aren't motivated by pure health reasons, whether it's the food pyramid or all these things are So I don't want to get deep into that, but I just want to say, because some people are like, Well, why did that happen? or whatever