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This is not a sign that the drug "stopped working." It reflects that the drug was doing the work, and without it, the underlying biology resumes
doi:10.1016/j.arth.2023.05.071 Magruder ML, Miskiewicz MJ, Rodriguez AN, Mont MA
DMF was also shown to diminish the metabolic flux of glutamine to the tricarboxylic acid (TCA) cycle and divert it towards GSH biosynthesis 26
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