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Long-term effects on body weight and metabolism Studies show that using semaglutide for a long time can help people lose a lot of weight

These numbers suggest that some of the headaches could be related to other things rather than the medication, but many real-world users continue to report new or worsening headaches after starting semaglutide, so it is worth considering that the two may be related

Retrieved December 10, 2025, from Devi S (2025) A review on Klotho: FGF23 mediated pathway integration and aging