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Thus, this ratings should be interpreted with caution in the context of in vitro study design

Yet, in many countries the devices being used to deliver GLP-1s are the same for both the weight loss and T2D populations and, in many cases, were originally designed for delivering insulin, such as Novo Nordisks FlexTouch pen (Wegovy, semaglutide) or Eli Lillys KwikPen (Mounjaro, tirzepatide) outside the US

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If you reach 6-8 weeks on an adequate dose with proper technique and see minimal results, the conversation with your provider should include discussing whether sublingual delivery is providing sufficient bioavailability for your needs, or whether transitioning to injectable administration might be more effective