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The compound does not appear to have carcinogenic activity in the models tested, and its interaction with tumor biology, a legitimate concern given that angiogenesis also supports tumor vascularization, has been examined in several studies without evidence of tumor promotion at physiological doses

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At present, several risk factors for asthma are universally recognised, yet there is a lack of routinely applied screening programmes for asthma in individuals at risk

Nature 365 , 797805 (1993)