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202,203 Essentially, the imported disulphide-containing proteins undergo cathepsin-catalysed degradation in the lysosome, leading to the formation of cystine, which is then effluxed by the cystinosin transporter into the cytosol, where it is reduced to cysteine in a process that requires NADPH, leading to the formation of oxidised glutathione
As many Rickettsia species target endothelial cells during systemic infection 38 , we determined the effects of BSO on infected human microvascular endothelial cells (HMEC-1)
J Trace Elem Med Biol
LL-37 is already overexpressed in your plaques and helps activate the dendritic cells that drive the disease (Lande et al., Nature, 2007)
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