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However, increasing oral supplement doses (within safe limits) while awaiting medical review is generally considered safe, as B12 has very low toxicity and excess is excreted through the kidneys
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Emerging therapeutic strategies aim to target these pathways specifically like MATs, NOX inhibitors, and Nrf2 activators, though clinical success has been limited by off-target effects and the dual role of ROS in physiological signaling (Pergola et al., 2021)
doi: 10.1681/asn.2020030326 16 McEvoyCMMurphyJMZhangLClotet-FreixasSMathewsJAAnJet al
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