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This is a known phenomenon where neurons that had adapted to chronic hyperglycemia react adversely to rapid glycemic normalization
The STEP (Semaglutide Treatment Effect in People with obesity) clinical trial program, which evaluated once-weekly semaglutide 2.4 mg for weight management, demonstrated significant weight loss (approximately 15% in STEP 1) that could indirectly affect hormone levels, though testosterone was not systematically reported in these publications
Rapid progress generates excitement and motivation
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