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Symptoms of vitamin B12 deficiency can vary widely and may include fatigue, weakness, pale skin, shortness of breath, neurological symptoms such as numbness or tingling in the hands and feet, difficulty walking, memory loss, and mood changes

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It is also independently associated with abnormal lipid metabolism as well as an increased risk of cardiovascular and cerebrovascular disease compared to E3 and E2 alleles (Belloy et al., 2019

It binds with high affinity to hepatocyte growth factor (HGF) and interacts with its receptor, c-Met