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No human trial has tested the best time, however
Animal experimental evidence Osteoclast precursor (RAW264.7) experiment: AOD 9604 significantly inhibited RANKL induced osteoclast formation, reduced the number of TRAP positive multinucleated cells, and decreased bone resorption pit formation
The dose is then increased in 2.5 mg increments every 4 weeks as tolerated, with typical maintenance doses ranging from 5 mg to 15 mg
It also has anti-inflammatory and oxidative stress-reducing effects that may contribute to its antidepressant activity, and has been shown to inhibit depression-like signaling in brains of healthy volunteers
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